A Potent Mu-Opioid Receptor Agonist, Dihydroetorphine, Fails to Produce the Conditioned Place Preference in Mice

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Author(s)

    • TOKUYAMA Shogo
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
    • NAKAMURA Fumihiro
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
    • NAKAO Kaoru
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
    • TAKAHASHI Masakatsu
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
    • KANETO Hiroshi
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University

Abstract

Reinforcing effects of dihydroetorphine (DHE) and morphine were evaluated by the conditioned place preference paradigm. Both DHE and morphine produced an antinociceptive effect in a dose-dependent manner. On the other hand, DHE (0.1, 1, 3 and 10 μg/kg, i.p.) failed to induce the conditioned preference, while morphine (0.1, 1, 3 and 10 mg/kg, i.p.) caused a dose-dependent preference for the drug-paired place. Thus, these characteristic properties of DHE make it attractive for development as a novel potent analgesic compound that has less dependence liability.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 71(4), 357-360, 1996-08-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008189416
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • Data Source
    CJP  J-STAGE 
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