A Potent Mu-Opioid Receptor Agonist, Dihydroetorphine, Fails to Produce the Conditioned Place Preference in Mice.

• Tokuyama Shogo

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University

• Nakamura Fumihiro

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University

• Nakao Kaoru

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University

• Takahashi Masakatsu

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University

• Kaneto Hiroshi

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University

Abstract

Reinforcing effects of dihydroetorphine (DHE) and morphine were evaluated by the conditioned place preference paradigm. Both DHE and morphine produced an antinociceptive effect in a dose-dependent manner. On the other hand, DHE (0.1, 1, 3 and 10 μg/kg, i.p.) failed to induce the conditioned preference, while morphine (0.1, 1, 3 and 10 mg/kg, i.p.) caused a dose-dependent preference for the drug-paired place. Thus, these characteristic properties of DHE make it attractive for development as a novel potent analgesic compound that has less dependence liability.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 71 (4), 357-360, 1996

  The Japanese Pharmacological Society

Keywords

• Dihydroetorphine
• Morphine
• Conditioned place preference

Details

• CRID: 1390282679264459008
• NII Article ID: 10008189416
• NII Book ID: AA00691188
• DOI: 10.1254/jjp.71.357
• COI: 1:CAS:528:DyaK28XltlKls7o%3D
• ISSN: 13473506
• ISSN: 00215198
• PubMed: 8886936
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819352606?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819352606?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/1997009362
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed