Effects of Sematilide, a Novel Class III Antiarrhythmic Agent, on Delayed Rectifier K^+ Current in Guinea Pig Atrial Myocytes

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Author(s)

    • ISHII Yasunori
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
    • MURAKI Katsuhiko
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
    • IMAIZUMI Yuji
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
    • WATANABE Minoru
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University

Abstract

Effects of sematilide, a novel class III antiarrhythmic agent, on the delayed rectifier K<SUP>+</SUP> current (I<SUB>K</SUB>) were examined in guinea pig atrial myocytes using a voltage clamp technique. Sematilide inhibited both time-dependent outward current upon depolarization and tail currents (I<SUB>K-tail</SUB>) at −40 mV. The concentration of sematilide required for a 50% decrease in I<SUB>K-tail</SUB> was approximately 50 μM. The sematilidesensitive current obtained using a triangular voltage command exhibited marked inward rectification and had the maximum amplitude at −30 mV. These results suggest that sematilide inhibits rapidly activating I<SUB>K</SUB> in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 71(4), 361-365, 1996-08-01

    The Japanese Pharmacological Society

References:  14

Codes

  • NII Article ID (NAID)
    10008189432
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • Data Source
    CJP  J-STAGE 
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