Effects of Sematilide, a Novel Class III Antiarrhythmic Agent, on Delayed Rectifier K+ Current in Guinea Pig Atrial Myocytes.
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- Ishii Yasunori
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University Biology Section, Shirakawa Laboratory, Nippon Roussel Co., Ltd.
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- Muraki Katsuhiko
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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- Kurihara Atsushi
- Biology Section, Shirakawa Laboratory, Nippon Roussel Co., Ltd.
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- Imaizumi Yuji
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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- Watanabe Minoru
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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Abstract
Effects of sematilide, a novel class III antiarrhythmic agent, on the delayed rectifier K+ current (IK) were examined in guinea pig atrial myocytes using a voltage clamp technique. Sematilide inhibited both time-dependent outward current upon depolarization and tail currents (IK-tail) at −40 mV. The concentration of sematilide required for a 50% decrease in IK-tail was approximately 50 μM. The sematilidesensitive current obtained using a triangular voltage command exhibited marked inward rectification and had the maximum amplitude at −30 mV. These results suggest that sematilide inhibits rapidly activating IK in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 71 (4), 361-365, 1996
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282679264471040
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- NII Article ID
- 10008189432
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK28XltlKls7s%3D
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- ISSN
- 13473506
- 00215198
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- PubMed
- 8886937
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed