Effects of Sematilide, a Novel Class III Antiarrhythmic Agent, on Delayed Rectifier K+ Current in Guinea Pig Atrial Myocytes.

DOI Web Site Web Site PubMed 25 References
  • Ishii Yasunori
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University Biology Section, Shirakawa Laboratory, Nippon Roussel Co., Ltd.
  • Muraki Katsuhiko
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
  • Kurihara Atsushi
    Biology Section, Shirakawa Laboratory, Nippon Roussel Co., Ltd.
  • Imaizumi Yuji
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
  • Watanabe Minoru
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University

Search this article

Abstract

Effects of sematilide, a novel class III antiarrhythmic agent, on the delayed rectifier K+ current (IK) were examined in guinea pig atrial myocytes using a voltage clamp technique. Sematilide inhibited both time-dependent outward current upon depolarization and tail currents (IK-tail) at −40 mV. The concentration of sematilide required for a 50% decrease in IK-tail was approximately 50 μM. The sematilidesensitive current obtained using a triangular voltage command exhibited marked inward rectification and had the maximum amplitude at −30 mV. These results suggest that sematilide inhibits rapidly activating IK in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness.

Journal

References(25)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top