Inhibition by Aminosalicylates of Lipid Peroxidation in Large Intestinal Mucosa after Mesenteric Ischemia/Reperfusion in the Rat

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Author(s)

Abstract

To clarify the mode of action of aminosalicylates, which are generally used as therapeutic agents for ulcerative colitis, we investigated the effect of some of the aminosalicylates on lipid peroxidation in the large intestinal mucosa after mesenteric ischemia/reperfusion in the rat. Lipid peroxidation was assessed by measuring the level of thiobarbituric-acid-reactive substances. It was found that aminosalicylates dose-dependently inhibited the elevation of the level of thiobarbituric-acid-reactive substances in the large intestinal mucosa after ischemia/reperfusion. This effect may partly contribute to the therapeutic actions of aminosalicylates in ulcerative colitis.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 75(2), 187-189, 1997-10-01

    The Japanese Pharmacological Society

References:  8

Codes

  • NII Article ID (NAID)
    10008189733
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4326417
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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