Comparative Study of the Effects of Indomethacin and NS-398, a Selective Cyclooxygenase 2 Inhibitor, on Duodenal Bicarbonate Secretion Induced by Luminal Acidification in Rats.

• Iwata Kazumi

  Research and Development Laboratories, Maruho Co.

• Murakami Naofumi

  Research and Development Laboratories, Maruho Co.

• Takase Hiroshi

  Research and Development Laboratories, Maruho Co.

• Saito Takako

  Research and Development Laboratories, Maruho Co.

• Naruse Tomohiro

  Research and Development Laboratories, Maruho Co.

書誌事項

タイトル別名

• Comparative Study of the Effects of Ind

抄録

To clarify the mechanisms of duodenal ulcerogenic activity of non-steroidal anti-inflammatory drugs (NSAIDs), the effects of indomethacin (IND) on acid-stimulated duodenal bicarbonate secretion and histamine-induced duodenal ulcerogenic responses were studied in comparison with NS-398, a selective cyclooxygenase (COX)-2 inhibitor, in rats. IND (1 and 5 mg/kg, s.c.) significantly decreased duodenal bicarbonate secretion and potentiated duodenal lesion in a dose-dependent manner. On the other hand, NS-398 had no effect on these parameters. These findings suggest that duodenal ulcerogenicity of IND in the presence of histamine is mainly due to the inhibitory action on acid-stimulated bicarbonate secretion mediated by COX-1, but not by COX-2.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 75 (2), 191-194, 1997

  公益社団法人 日本薬理学会

キーワード

• Indomethacin
• NS-398
• Duodenal bicarbonate

詳細情報

• CRID: 1390282679261992064
• NII論文ID: 10008189742
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.75.191
• COI: 1:CAS:528:DyaK2sXntVKmurk%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 4326418
• PubMed: 9414035
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4326418
• Web Site: https://search.jamas.or.jp/link/ui/1998166289
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可