Effects of Concanavalin A on Cytokine mRNA Expression in Mouse Liver

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Author(s)

Abstract

The effects of concanavalin A (Con A) on liver cytokine gene expression was studied in mice. The CD4 mRNA expression in normal liver suggests the presence of CD4<SUP>+</SUP> T cells. The administration of Con A induced interleukin (IL) 1β, IL-2 and IL-2 receptor mRNAs, which implies lymphocyte activation in the liver. Interferon-γ and tumor necrosis factor-α mRNA expressions were increased gradually. The present results showed that Con A induced liver cytokine genes. This cytokine gene induction might have been the result of lymphocyte activation in the liver.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 75(2), 199-201, 1997-10-01

    The Japanese Pharmacological Society

References:  11

Cited by:  8

Codes

  • NII Article ID (NAID)
    10008189772
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4326420
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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