Inhibitory Effect of Lomerizine, a Diphenylpiperazine Ca^<2+>-Channel Blocker, on Ba^<2+> Current through Voltage-Gated Ca^<2+> Channels in PC12 Cells

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We investigated the effect of lomerizine, an anti-migraine drug, on the Ba<SUP>2+</SUP> current through voltage-gated Ca<SUP>2+</SUP> channels in rat pheochromocytoma (PC12) cells using a whole-cell voltage-clamp technique. Lomerizine inhibited the Ba<SUP>2+</SUP> current with an IC<SUB>50</SUB> value of 1.9 μM. Lomerizine and nicardipine were > 4 times more potent than flunarizine, diltiazem, verapamil and dimetotiazine. The time course of inactivation induced by lomerizine was similar to that induced by nicardipine and flunarizine. These data indicate that lomerizine may inhibit the Ca<SUP>2+</SUP> channel in a similar manner to nicardipine and flunarizine, and its potency is almost equal to that of nicardipine.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 75(2), 209-213, 1997-10-01

    公益社団法人 日本薬理学会

参考文献:  18件中 1-18件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008189800
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4326422
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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