Inhibitory Effect of Lomerizine, a Diphenylpiperazine Ca^<2+>-Channel Blocker, on Ba^<2+> Current through Voltage-Gated Ca^<2+> Channels in PC12 Cells

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Author(s)

Abstract

We investigated the effect of lomerizine, an anti-migraine drug, on the Ba<SUP>2+</SUP> current through voltage-gated Ca<SUP>2+</SUP> channels in rat pheochromocytoma (PC12) cells using a whole-cell voltage-clamp technique. Lomerizine inhibited the Ba<SUP>2+</SUP> current with an IC<SUB>50</SUB> value of 1.9 μM. Lomerizine and nicardipine were > 4 times more potent than flunarizine, diltiazem, verapamil and dimetotiazine. The time course of inactivation induced by lomerizine was similar to that induced by nicardipine and flunarizine. These data indicate that lomerizine may inhibit the Ca<SUP>2+</SUP> channel in a similar manner to nicardipine and flunarizine, and its potency is almost equal to that of nicardipine.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 75(2), 209-213, 1997-10-01

    The Japanese Pharmacological Society

References:  18

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008189800
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4326422
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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