Lipid Peroxidation in the Pancreas and Other Organs in Streptozotocin Diabetic Rats.

• Tatsuki Rie

  Department of Pharmacology, Hokkaido College of Pharmacy

• Satoh Kumi

  Department of Pharmacology, Hokkaido College of Pharmacy

• Yamamoto Atsuko

  Department of Pharmacology, Hokkaido College of Pharmacy

• Hoshi Katsuji

  Department of Pharmacology, Hokkaido College of Pharmacy

• Ichihara Kazuo

  Department of Pharmacology, Hokkaido College of Pharmacy Department of Clinical Pharmacology, Asahikawa Medical College

Bibliographic Information

Other Title

• Lipid Peroxidation in the Pancreas and

Abstract

We studied the relationship between changes in lipid peroxides and those in catalase activity in pancreases, livers and hearts of streptozotocin-induced diabetic rats. Animals were killed 2 or 7 weeks after saline or streptozotocin (32 mg/kg, i.v.) injection. The levels of blood glucose and plasma insulin in the 2-week streptozotocin-treated rats were 176.8 ± 20.5 mg/dl and 29.9 ± 3.2 μU/ml, respectively. In the pancreas, the lipid peroxide level significantly decreased and the catalase activity significantly increased 2 weeks after streptozotocin injection. These changes recovered after 7 weeks. In the heart, the lipid peroxide level significantly increased without any change of catalase activity 2 weeks after the initiation of diabetes. After 7 weeks, the catalase activity significantly increased and the lipid peroxide level returned to the control level. In the liver, there was no change in the lipid peroxides and catalase in the 2-week streptozotocintreated rats, whereas the catalase activity significantly increased 7 weeks after the injection. It was suggested that the defense system in the pancreas to oxidative stress may be evoked in an early stage of streptozotocin-induced diabetes.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 75 (3), 267-273, 1997

  The Japanese Pharmacological Society

Keywords

• Streptozotocin
• Lipid peroxide
• Catalase
• Liver
• Heart

Details

• CRID: 1390282679263346048
• NII Article ID: 10008190043
• NII Book ID: AA00691188
• DOI: 10.1254/jjp.75.267
• COI: 1:CAS:528:DyaK2sXnsFWmu7o%3D
• ISSN: 13473506
• ISSN: 00215198
• ISSN: http://id.crossref.org/issn/00215198
• NDL BIB ID: 4346257
• PubMed: 9434258
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4346257
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819313058?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819313058?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/1998081091
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed