Contribution of Bradykinin to the Cardioprotective Action of Angiotensin Converting Enzyme Inhibition in Hypertension and After Myocardial Infarction

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Author(s)

    • Ito Katsuhiko ITO Katsuhiko
    • Department of Pharmacology, Christian-Albrechts University of Kiel, HospitalstraBe4, 24105 Kiel, and German Institute for High Blood Pressure Research
    • Zhu Yi-Zhun ZHU Yi-Zhun
    • Department of Pharmacology, Christian-Albrechts University of Kiel, HospitalstraBe4, 24105 Kiel, and German Institute for High Blood Pressure Research
    • Zhu Yi-Chun [他] ZHU Yi-Chun
    • Department of Pharmacology, Christian-Albrechts University of Kiel, HospitalstraBe4, 24105 Kiel, and German Institute for High Blood Pressure Research
    • GOHLKE Peter
    • Department of Pharmacology, Christian-Albrechts University of Kiel, HospitalstraBe4, 24105 Kiel, and German Institute for High Blood Pressure Research
    • UNGER Thomas
    • Department of Pharmacology, Christian-Albrechts University of Kiel, HospitalstraBe4, 24105 Kiel, and German Institute for High Blood Pressure Research

Abstract

Angiotensin converting enzyme (ACE) is identical with kininase II. Besides reducing the production of angiotensin II, inhibition of ACE potentiates the biological actions of endogenous kinins. In hypertension-induced left ventricular hypertrophy, potentiation of endogenous kinins contributes to the improvement of cardiac function and energy metabolism and to capillary proliferation effected by ACE inhibitors. In myocardial infarction (MI), the potentiation of kinins has been shown to be involved in the reduction of infarct size and improvement of cardiac function by ACE inhibition. The cardioprotective actions of ACE inhibition in MI seem to be, in part, mediated by the augmentation of myocardial blood flow, especially in the ischemic region of the heart.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 75(4), 311-318, 1997-12-01

    The Japanese Pharmacological Society

References:  69

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008190205
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4371096
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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