Contribution of Bradykinin to the Cardioprotective Action of Angiotensin Converting Enzyme Inhibition in Hypertension and After Myocardial Infarction

この論文にアクセスする

この論文をさがす

著者

    • Ito Katsuhiko ITO Katsuhiko
    • Department of Pharmacology, Christian-Albrechts University of Kiel, HospitalstraBe4, 24105 Kiel, and German Institute for High Blood Pressure Research
    • Zhu Yi-Zhun ZHU Yi-Zhun
    • Department of Pharmacology, Christian-Albrechts University of Kiel, HospitalstraBe4, 24105 Kiel, and German Institute for High Blood Pressure Research
    • Zhu Yi-Chun [他] ZHU Yi-Chun
    • Department of Pharmacology, Christian-Albrechts University of Kiel, HospitalstraBe4, 24105 Kiel, and German Institute for High Blood Pressure Research
    • GOHLKE Peter
    • Department of Pharmacology, Christian-Albrechts University of Kiel, HospitalstraBe4, 24105 Kiel, and German Institute for High Blood Pressure Research
    • UNGER Thomas
    • Department of Pharmacology, Christian-Albrechts University of Kiel, HospitalstraBe4, 24105 Kiel, and German Institute for High Blood Pressure Research

抄録

Angiotensin converting enzyme (ACE) is identical with kininase II. Besides reducing the production of angiotensin II, inhibition of ACE potentiates the biological actions of endogenous kinins. In hypertension-induced left ventricular hypertrophy, potentiation of endogenous kinins contributes to the improvement of cardiac function and energy metabolism and to capillary proliferation effected by ACE inhibitors. In myocardial infarction (MI), the potentiation of kinins has been shown to be involved in the reduction of infarct size and improvement of cardiac function by ACE inhibition. The cardioprotective actions of ACE inhibition in MI seem to be, in part, mediated by the augmentation of myocardial blood flow, especially in the ischemic region of the heart.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 75(4), 311-318, 1997-12-01

    公益社団法人 日本薬理学会

参考文献:  69件中 1-69件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008190205
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00215198
  • NDL 記事登録ID
    4371096
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
ページトップへ