Contribution of Bradykinin to the Cardioprotective Action of Angiotensin Converting Enzyme Inhibition in Hypertension and After Myocardial Infarction.

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  • Ito Katsuhiko
    Department of Pharmacology, Christian-Albrechts University of Kiel German Institute for High Blood Pressure Research
  • Zhu Yi-Zhun
    Department of Pharmacology, Christian-Albrechts University of Kiel German Institute for High Blood Pressure Research
  • Zhu Yi-Chun
    Department of Pharmacology, Christian-Albrechts University of Kiel German Institute for High Blood Pressure Research
  • Gohlk Peter
    Department of Pharmacology, Christian-Albrechts University of Kiel German Institute for High Blood Pressure Research
  • Unger Thomas
    Department of Pharmacology, Christian-Albrechts University of Kiel German Institute for High Blood Pressure Research

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タイトル別名
  • Contribution of Bradykinin to the Cardi

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抄録

Angiotensin converting enzyme (ACE) is identical with kininase II. Besides reducing the production of angiotensin II, inhibition of ACE potentiates the biological actions of endogenous kinins. In hypertension-induced left ventricular hypertrophy, potentiation of endogenous kinins contributes to the improvement of cardiac function and energy metabolism and to capillary proliferation effected by ACE inhibitors. In myocardial infarction (MI), the potentiation of kinins has been shown to be involved in the reduction of infarct size and improvement of cardiac function by ACE inhibition. The cardioprotective actions of ACE inhibition in MI seem to be, in part, mediated by the augmentation of myocardial blood flow, especially in the ischemic region of the heart.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 75 (4), 311-318, 1997

    公益社団法人 日本薬理学会

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