Effects of Kamikihi-To, a Traditional Chinese Medicine, on Behavioral Changes Induced by Methyl-β-carboline-3-carboxylate in Mice and Rats

Access this Article

Author(s)

Abstract

he effects of Kamikihi-To (KMK), a traditional Chinese medicine, on behavioral changes induced by methyl-β-carboline-3-carboxylate (β-CCM) were evaluated in mice and rats. β-CCM, an anxiogenic benzodiazepine receptor inverse agonist (3.0 mg/kg, i.v. administered 1 min before the test), decreased the locomotor activity of mice in a novel environment. Furthermore, β-CCM (0.1 mg/kg, i.v. administered 10 min before the test) facilitated the suppression of drinking behavior induced by punishment in the water lick conflict test in rats. KMK (1.0 and 2.0 g/kg, p.o. administered 1 hr before the test) antagonized the decreased locomotor activity in the β-CCM-treated mice. KMK (2.0 g/kg, p.o.) also recovered the suppression of drinking behavior in the β-CCM-treated rats. KMK (2.0 g/kg, p.o.) had no effect on β-CCM-untreated mice and rats in these tests. These findings suggest that KMK has a protective effect against β-CCM-induced behavioral changes.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 75(4), 391-397, 1997-12-01

    The Japanese Pharmacological Society

References:  25

Codes

  • NII Article ID (NAID)
    10008190537
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00215198
  • NDL Article ID
    4371105
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
Page Top