Effects of Xanthine Derivatives on Phosphatidylcholine Secretion in Rat Type II Pneumocytes in the Presence of Activated Eosinophils.
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- Okumura Manabu
- Department of Pharmacy, Miyazaki Medical College Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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- Kai Hirofumi
- Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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- Shinozawa Shinya
- Department of Pharmacy, Miyazaki Medical College
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- Isohama Yoichiro
- Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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- Takahama Kazuo
- Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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- Miyata Takeshi
- Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
Bibliographic Information
- Other Title
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- Effects of Xanthine Derivatives on Phosphatidylcholine Secretion in Rat Type 2 Pneumocytes in the Presence of Activated Eosinophils
- Effects of Xanthine Derivatives on Phos
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Abstract
We have previously reported that activated eosinophils enhanced the phosphatidylcholine (PC) secretion in type II pneumocytes. In this study, we have determined whether xanthine derivatives affect the PC secretion increased by activated eosinophils. Theophylline enhanced the increased PC secretion at 10-5 M. 8-Phenyltheophylline dose-dependently enhanced the PC secretion. The enhanced secretion by either theophylline at 10-5 M or 8-phenyltheophylline was suppressed by superoxide dismutase in combination with catalase. Pentoxifylline did not enhance the PC secretion increased by activated eosinophils, although it increased the PC secretion by itself. The PC secretion increased by theophylline at 10-3 M or pentoxifylline was not suppressed by superoxide dismutase in combination with catalase. The present results suggest that xanthine derivatives increased the PC secretion in the co-culture of type II pneumocytes and activated eosinophils possibly through the inhibition of phosphodiesterases or the antagonism of adenosine receptors of the eosinophils.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 75 (4), 425-432, 1997
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001204284724864
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- NII Article ID
- 10008190651
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1cXhtVym
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4371109
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- PubMed
- 9469649
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed