Effects of Xanthine Derivatives on Phosphatidylcholine Secretion in Rat Type 2 Pneumocytes in the Presence of Activated Eosinophils

• Okumura Manabu

  Department of Pharmacy, Miyazaki Medical College Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University

• Kai Hirofumi

  Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University

• Shinozawa Shinya

  Department of Pharmacy, Miyazaki Medical College

• Isohama Yoichiro

  Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University

• Takahama Kazuo

  Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University

• Miyata Takeshi

  Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University

書誌事項

タイトル別名

• Effects of Xanthine Derivatives on Phosphatidylcholine Secretion in Rat Type II Pneumocytes in the Presence of Activated Eosinophils.
• Effects of Xanthine Derivatives on Phos

抄録

We have previously reported that activated eosinophils enhanced the phosphatidylcholine (PC) secretion in type II pneumocytes. In this study, we have determined whether xanthine derivatives affect the PC secretion increased by activated eosinophils. Theophylline enhanced the increased PC secretion at 10^-5 M. 8-Phenyltheophylline dose-dependently enhanced the PC secretion. The enhanced secretion by either theophylline at 10^-5 M or 8-phenyltheophylline was suppressed by superoxide dismutase in combination with catalase. Pentoxifylline did not enhance the PC secretion increased by activated eosinophils, although it increased the PC secretion by itself. The PC secretion increased by theophylline at 10^-3 M or pentoxifylline was not suppressed by superoxide dismutase in combination with catalase. The present results suggest that xanthine derivatives increased the PC secretion in the co-culture of type II pneumocytes and activated eosinophils possibly through the inhibition of phosphodiesterases or the antagonism of adenosine receptors of the eosinophils.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 75 (4), 425-432, 1997

  公益社団法人 日本薬理学会

キーワード

• Pneumocyte (type II)
• Phosphatidylcholine secretion
• Eosinophil
• Superoxide anion
• Xanthine derivative

詳細情報

• CRID: 1390001204284724864
• NII論文ID: 10008190651
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.75.425
• COI: 1:CAS:528:DyaK1cXhtVym
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 4371109
• PubMed: 9469649
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4371109
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819312946?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819312946?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/1998088645
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可