Enhancement of Membrane Damage by Saponins Isolated from Acacia auriculiformis.
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- Babu Santi Prasad Sinha
- Parasitology Laboratory, Department of Zoology, Visva-Bharati University
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- Sarkar Debapriya
- Environmental Toxicology Laboratory, Department of Zoology, Visva-Bharati University
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- Ghosh Naba Kumar
- Parasitology Laboratory, Department of Zoology, Visva-Bharati University
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- Saha Arpita
- Parasitology Laboratory, Department of Zoology, Visva-Bharati University
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- Sukul Nirmal Chandra
- Parasitology Laboratory, Department of Zoology, Visva-Bharati University
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- Bhattacharya Shelley
- Environmental Toxicology Laboratory, Department of Zoology, Visva-Bharati University
書誌事項
- タイトル別名
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- Enhancement of Membrane Damage by Sapon
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Acaciaside A and B, two acylated triterpenoid bisglycosides isolated from the funicles of Acacia auriculiformis, are known to have antihelmintic activity. Since the saponins contain a conjugated unsaturated system that is highly susceptible to peroxidation, we investigated the interaction of saponins and membrane using rat liver microsomes as our model. Microsomal membranes were incubated with saponins at 30°C for 2 hr. Following incubation, lipid peroxidation was measured in terms of malondialdehyde and conjugated diene. Our results showed that incubation of microsomal membranes with saponins increased both malondialdehyde and conjugated diene. The results suggest that in our model, saponins enhance the membrane lipid peroxidation.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 75 (4), 451-454, 1997
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679261419776
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- NII論文ID
- 10008190768
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- NII書誌ID
- AA00691188
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- COI
- 1:STN:280:DyaK1c7ivFGmtA%3D%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 4371114
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- PubMed
- 9469654
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可