Diverse Relaxation Responses of Canine Large and Small Conductive Coronary Arteries to Glyceryl Trinitrate and Nitric Oxide on the One Hand and to 8-Bromoguanosine 3':5' Cyclic Monophosphate on the Other
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Glyceryl trinitrate (GTN) and nitric oxide (NO) preferentially relaxed the large (2 mm in diameter) conductive coronary artery (CCA) of the dog, while 8-bromoguanosine 3′:5′ cyclic monophosphate preferentially relaxed the small one (0.6 mm in diameter). Nither L-cysteine nor L-acetylcysteine affected GTN-induced relaxation in small- and large-CCA. These results indicate that not different biotransformation of GTN to NO, but a process or processes operative between activation of guanylate cyclase and that of cyclic GMP-dependent protein kinase seems to be responsible for the preferential dilatation of large-CCA.
- The Japanese Journal of Pharmacology
The Japanese Journal of Pharmacology 76(1), 101-104, 1998-01
The Japanese Pharmacological Society