The AMPA-Receptor Antagonist YM90K Reduces AMPA Receptor-Mediated Excitotoxicity in Rat Hippocampal Cultures

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Author(s)

    • Ohno Kazushige OHNO Kazushige
    • Neuroscience Research, Pharmacology Laboratiries, Institute for Drug Discavery Research, Yamanouchi Pharmaceutical Co., Ltd.
    • SAKAMOTO Shuichi
    • Neuroscience Research, Pharmacology Laboratiries, Institute for Drug Discavery Research, Yamanouchi Pharmaceutical Co., Ltd.
    • YAMAGUCHI Tokio
    • Neuroscience Research, Pharmacology Laboratiries, Institute for Drug Discavery Research, Yamanouchi Pharmaceutical Co., Ltd.

Abstract

The effects of YM90K on α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor-mediated excitotoxicity were investigated using kainate, AMPA and cyclothiazide in rat hippocampal cultures. YM90K had neuroprotective actions against both kainate toxicity and cyclothiazideenhanced AMPA toxicity. YM90K induced a parallel and rightward shift of both kainate and AMPA dose-response curves. The application of YM90K even 3 hr after the start of kainate exposure significantly reduced kainate toxicity. These results indicate that YM90K protects neurons against AMPA receptor-mediated toxicity at an agonist site on the AMPA receptor and that YM90K protects against AMPA receptor-mediated toxicity even if applied after neurotoxic insult.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 76(1), 105-108, 1998-01

    The Japanese Pharmacological Society

References:  14

Codes

  • NII Article ID (NAID)
    10008191259
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4395864
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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