Effect of Muscarinic Agonist on Overflow Incontinence Induced by Bilateral Pelvic Nerve Transection in Rats

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Author(s)

Abstract

The effect of bethanechol, a muscarinic agonist, was studied by cystometrography in conscious rats with bilateral pelvic nerve (PN) lesions. In sham-operated rats, the transvesical infusion of saline elicited regularly micturition. The micturition was abolished by the bilateral PN transection, resulting in overflow incontinence. Bethanechol (30 mg/kg), administered orally to denervated rats, significantly increased the micturition frequency. Therefore, the micturition seems to be largely dependent upon muscarinic receptors of the bladder, and the finding supports the clinical effect of bethanechol. Moreover, this animal model may be useful for studying the overflow incontinence from detrusor failure of neuropathic origin.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 76(1), 109-111, 1998-01

    The Japanese Pharmacological Society

References:  14

Codes

  • NII Article ID (NAID)
    10008191274
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4395865
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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