The Powerful Stimulatory Action of 6-O-Acetyl-9-methyl-7-bromoeudistomin D on the Contractile Protein System of Rabbit Skeletal Muscle

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Author(s)

Abstract

6-<I>O</I>-Acetyl-9-methyl-7-bromoeudistomin D (AMBED) (>10<SUP>-6</SUP> M), a derivative of eudistomin D, markedly enhanced the superprecipitation and the ATPase activity of skeletal muscle myosin B. In both the superprecipitation and ATPase activity of myosin B, the concentration-response curve for Ca<SUP>2+</SUP> was shifted upwards by AMBED. AMBED did not affect the Ca<SUP>2+</SUP>-, K<SUP>+</SUP>-EDTA- or Mg<SUP>2+</SUP>-ATPase of myosin or the ATPase of actomyosin reconstituted from actin and myosin. These results suggest that AMBED causes an increase in the actomyosin ATPase activity mediated through the elevation of the maximum response to Ca<SUP>2+</SUP>, resulting in enhancement of the superprecipitation of skeletal muscle myosin B.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 76(1), 113-116, 1998-01

    The Japanese Pharmacological Society

References:  15

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008191289
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4395866
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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