Two Distinct Effects of 12S-Hydroxyeicosatetraenoic Acid on Platelet Aggregation by Zooxanthellatoxin-A and Ionomycin

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Author(s)

Abstract

The marine toxin zooxanthellatoxin-A (ZT-A) and the Ca<SUP>2+</SUP> ionophore ionomycin caused aggregation in rabbit platelets. While ZT-A-induced platelet aggregation was inhibited by indomethacin, ionomycin-induced aggregation was potentiated by the drug. In contrast, both ZT-A- and ionomycininduced accumulations of thromboxane B<SUB>2</SUB> (TXB<SUB>2</SUB>), a stable metabolite of thromboxane A<SUB>2</SUB> (TXA<SUB>2</SUB>), were completely inhibited by indomethacin. 12<I>S</I>-Hydroxyeicosatetraenoic acid (12-HETE), which could be accumulated in the presence of indomethacin, inhibited ZT-A-induced aggregation, but it potentiated the ionomycin-induced one. These results suggest that the different effects of indomethacin may be attributed to the distinct effects of 12-HETE on ZT-A- and ionomycin-induced platelet aggregations.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 76(1), 117-120, 1998-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008191305
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4395867
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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