Possible Involvement of K_<ATP> Channel Activation in Depressor Responses to Vasoactive Neuropeptides in Rats

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Author(s)

Abstract

I.v. bolus injections of vasoactive intestinal polypeptide (VIP) (0.3 or 1 μg/kg), calcitonin gene-related peptide (CGRP) (0.3 μg/kg) or substance P (0.1 μg/kg) to anesthetized rats reduced blood pressure, accompanied by slight increases in heart rate. Cromakalim (0.3 μg/kg/min) infused i.v. significantly potentiated the depressor responses to VIP and CGRP, but not those to substance P and acetylcholine (ACh) (0.1 μg/kg). Glibenclamide (20 mg/kg, i.v.) significantly inhibited not only the depressor responses to VIP and CGRP, but also the augmentation of the effects of the two agents by cromakalim. These results suggest that the depressor responses to VIP and CGRP are mediated in part through K<SUB>ATP</SUB> channel activation.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 76(2), 227-231, 1998-02

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008191712
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4416251
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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