Treatment With Bovine Gallstones Exacerbates Liver Damage, but Enhances Hepatoprotection by Bear Gall Powder in Carbon Tetrachloride-Intoxicated Rats

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Author(s)

Abstract

The interactions between bovine gallstones (Goou) and bear gall powder (Yutan) in decreases in serum transaminase levels were investigated in rats intoxicated with carbon tetrachloride (CCl<SUB>4</SUB>). The p.o. administration of Goou significantly increased both serum transaminase levels and hepatic lipid peroxidation following i.p. administration of CCl<SUB>4</SUB>. Concomitant administration of both Goou and Yutan resulted in decreases of serum transaminase levels and hepatic lipid peroxidation, which were more remarkable than with administration of Yutan alone. Goou significantly increased the estimated hepatic blood flow in the indocyanine green clearance test and enhanced the delivery of CCl<SUB>4</SUB> to the liver from the peritoneal cavity. These findings suggest that Goou exacerbates CCl<SUB>4</SUB>-induced hepatic damage because of the accelerated delivery of CCl<SUB>4</SUB> to the liver and that Goou might have a hemodynamic drug interaction with Yutan in the liver, possibly enhancing the hepatoprotective effect of Yutan.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 76(3), 271-277, 1998-03

    The Japanese Pharmacological Society

References:  29

Codes

  • NII Article ID (NAID)
    10008191971
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00215198
  • NDL Article ID
    4440446
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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