Effect of Tazarotene, an Acetylenic Retinoid, on Human Dermal Fibroblast

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Author(s)

Abstract

The inhibitory effect of tazarotene, an acetylenic retinoid, on human dermal fibroblast in vitro was compared to that of all-<I>trans</I>-retinoic acid. The proliferation of fibroblasts was inhibited by both retinoids at the concentration of 1 μM after 5 days of culture. Synthesis of DNA and collagen was inhibited by both retinoids concentration-dependently up to 10 μM, although tazarotene was weaker in the inhibition of collagen synthesis. These results suggest the possible usefulness of tazarotene in the treatment of fibrotic diseases.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 76(3), 317-319, 1998-03

    The Japanese Pharmacological Society

References:  14

Codes

  • NII Article ID (NAID)
    10008192140
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4440453
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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