Role of Bradykinin in the Reduction of Left Ventricular Hypertrophy Induced by Angiotensin-Converting Enzyme Inhibitors in Spontaneously Hypertensive Rats
Access this Article
Search this Article
We examined the effects of icatibant, a specific bradykinin B<SUB>2</SUB>-receptor antagonist, on the regression of left ventricular mass (LVM) induced by angiotensin converting enzyme (ACE) inhibitors, ramipril and imidapril, in spontaneously hypertensive rats. Both ramipril and imidapril lowered blood pressure equally, which were not influenced by icatibant. Icatibant did not alter the regressive effect of imidapril, while it showed a tendency to increase LVM in the ramipril-treated rats. The changes of LVM induced by icatibant were significantly different between the ramipril- and the imidapril-treated rats, suggesting that the role of bradykinin in the antihypertrophic effect might differ among ACE inhibitors.
- The Japanese Journal of Pharmacology
The Japanese Journal of Pharmacology 76(4), 431-434, 1998-04-01
The Japanese Pharmacological Society