Different Chronotropic and Inotropic Effects of EMD 57033 and EMD 53998, Ca^<2+> Sensitizers, on Isolated, Blood-Perfused Dog Heart Preparations

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To investigate whether a Ca<SUP>2+</SUP> sensitizer increases sinus rate, we studied the effects of racemic thiadiazinone, EMD 53998 (a Ca<SUP>2+</SUP> sensitizer with phosphodiesterase inhibitory action) and its (+)-enantiomer EMD 57033 (a relatively pure Ca<SUP>2+</SUP> sensitizer) on isolated, blood-perfused spontaneously beating right atria and paced left ventricles of the dogs. EMD 53998 increased sinus rate dose-dependently, but EMD 57033 did not. Both substances increased atrial and ventricular contractile force. Propranolol did not affect the responses to each substance. These results suggest that the Ca<SUP>2+</SUP> sensitizing action induced by EMD 57033 does not affect pacemaker currents directly.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 76(4), 435-439, 1998-04-01

    公益社団法人 日本薬理学会

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各種コード

  • NII論文ID(NAID)
    10008192771
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4462601
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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