Different Chronotropic and Inotropic Effects of EMD 57033 and EMD 53998, Ca^<2+> Sensitizers, on Isolated, Blood-Perfused Dog Heart Preparations

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Author(s)

Abstract

To investigate whether a Ca<SUP>2+</SUP> sensitizer increases sinus rate, we studied the effects of racemic thiadiazinone, EMD 53998 (a Ca<SUP>2+</SUP> sensitizer with phosphodiesterase inhibitory action) and its (+)-enantiomer EMD 57033 (a relatively pure Ca<SUP>2+</SUP> sensitizer) on isolated, blood-perfused spontaneously beating right atria and paced left ventricles of the dogs. EMD 53998 increased sinus rate dose-dependently, but EMD 57033 did not. Both substances increased atrial and ventricular contractile force. Propranolol did not affect the responses to each substance. These results suggest that the Ca<SUP>2+</SUP> sensitizing action induced by EMD 57033 does not affect pacemaker currents directly.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 76(4), 435-439, 1998-04-01

    The Japanese Pharmacological Society

References:  13

Codes

  • NII Article ID (NAID)
    10008192771
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4462601
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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