Inhibitory Effects of Corymine-Related Compounds on Glycine Receptors Expressed in Xenopus Oocytes

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Author(s)

    • SUBHADHIRASAKUL Sanan
    • Department of Pharmaceutical Botany and Pharmacognosy, Faculty of Pharmaceutical Sciences, Prince of Songkhla University
    • AIMI Norio
    • Faculty of Pharmaceutical Sciences, Chiba University
    • WATANABE Hiroshi
    • Department of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University

Abstract

We examined the effects of 4 corymine-related compounds on glycine-induced chloride current in <I>Xenopus</I> oocytes. Dihydrocorymine, <I>N</I>-demethyl-3-epi-dihydrocorymine and deformylcorymine dose-dependently decreased the glycine current with IC<SUB>50</SUB> values of 34, 37 and 55 μM, respectively. The effect of these compounds on the glycine current was more potent than that of pleiocarpamine (IC<SUB>50</SUB> > 1 mM). <I>N</I>-Demethyl-3-epi-dihydrocorymine and dihydrocorymine, at 100 μM, also decreased the γ-aminobutyric acid-induced current by 65% and 22%, respectively, whereas deformylcorymine and pleiocarpamine failed. The inhibitory action of deformylcorymine on the glycine current was noncompetitive. These results suggest that deformylcorymine is a novel specific noncompetitive glycine receptor antagonist. The structure-activity relationship of these compounds was discussed.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 77(2), 169-172, 1998-06-01

    The Japanese Pharmacological Society

References:  8

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008193068
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4514093
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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