Effects of Transforming Growth Factor Alpha and Hepatocyte Growth Factor on Acid-Induced Damage in Rat Gastric Epithelial Cells

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Author(s)

Abstract

We examined the effects of transforming growth factor alpha (TGF-α) and hepatocyte growth factor (HGF) on acid-induced damage in a rat gastric epithelial cell line. Pretreatment of cells for 30 min with TGF-α, but not HGF, significantly prevented the acid-induced cell damage in a concentration-dependent manner. Genistein significantly reduced the protective effect of TGF-α. DNA synthesis in RGM1 cells was increased when the cells were incubated with TGF-α and HGF for 24 hr. We conclude that the protective effect of TGF-α against acid-induced damage seems to be caused by the activation of Na<SUP>+</SUP>/H<SUP>+</SUP> exchangers and not by enhanced DNA synthesis.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 77(2), 173-176, 1998-06-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008193077
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4514094
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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