Pancreatic Enzyme-Induced Pancreatitis and Systemic Complications in Rats

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Author(s)

Abstract

Effects of retrograde injection into the pancreatic duct and intravenous infusion of pancreatic enzymes and bile salt on the pancreas and other vital organs such as the liver and the lung were investigated in rats. Intraductal injection (1 ml/kg) of α-chymotrypsin (50 - 100 mg/ml), trypsin (10 - 100 mg/ml), pancreatic elastase (10 mg/ml), lipase (100 - 300 mg/ml), pancreatic kallikrein (25 mg/ml) and sodium taurocholate (50 mg/ml) solutions significantly increased pancreatic water content. α-Chymotrypsin, pancreatic elastase, taurocholate and trypsin elicited gross pancreatic hemorrhage. In contrast, lipase and kallikrein elicited gross pancreatic edema, but not hemorrhage. Intravenous infusion of trypsin (1 mg/kg/hr) and pancreatic elastase (10 mg/kg/hr) significantly increased pulmonary vascular permeability in rats, whereas infusion of neutrophil elastase (0.3 mg/kg/hr) did not elicit these effects. Only trypsin slightly reduced arterial oxygen pressure. These results show pancreatic enzymes and bile salts induce pancreatic inflammation after retrograde injection into the pancreatic duct in rats. Furthermore, trypsin and pancreatic elastase extravasation into the vascular system can lead to pulmonary dysfunction in rats.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 77(3), 185-191, 1998-07-01

    The Japanese Pharmacological Society

References:  27

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008193124
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4525734
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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