Effects of Sodium Nitroprusside on the Catecholamine Synthetic Pathway in the Adrenal Medulla of Rats

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Author(s)

Abstract

We studied the effect of sodium nitroprusside (SNP), a nitric oxide (NO) donor, on tyrosine hydroxylase (TH) activity and epinephrine and norepinephrine levels in the adrenal medulla of rats. TH activity and the levels of epinephrine and norepinephrine in the adrenal medulla of the SNP+nicotine (Nic)-treated group were increased significantly compared to those in the control, Nic-treated and SNP-treated groups. Furthermore, methylene blue inhibited this increase in TH activity. The data suggest that the NO derived from SNP may increase TH through the guanylyl cyclase pathway in the presence of Nic.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 77(3), 205-210, 1998-07-01

    The Japanese Pharmacological Society

References:  21

Codes

  • NII Article ID (NAID)
    10008193180
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00215198
  • NDL Article ID
    4525736
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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