Effects of Talipexole on Contraversive Rotation and Functional Impairment in MPTP-Induced Chronic Hemiparkinsonian Monkeys

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Author(s)

Abstract

The effects of talipexole on functional motor improvement in comparison with contraversive circling were studied in five chronic (5 - 7 years post MPTP-lesioned) hemiparkinsonian <I>Macaca nemestrina</I> monkeys. Talipexole induced contraversive rotations in a dose of 32 μg/kg for about 1 hr after i.m. injection. Larger doses (56 and 100 μg/kg, i.m.) produced less effect due to sedation. Three different rating scales were used to assess functional improvement, including a clinical parkinsonism rating scale, volitional responses to fruit presentations, and number of significant hand movements. The optimal dose of talipexole was 32 μg/kg, i.m. Functional improvement by talipexole, including clinical parkinsonian rating scales and significant hand movements, as well as contraversive circling in hemiparkinsonian monkeys, confirm that this chronic animal model is useful in preclinical testing of drugs for the treatment of human parkinsonism.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 77(3), 227-233, 1998-07-01

    The Japanese Pharmacological Society

References:  17

Codes

  • NII Article ID (NAID)
    10008193252
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00215198
  • NDL Article ID
    4525739
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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