The Effect of Acute Cold Exposure and Norepinephrine on Uncoupling Protein Gene Expression in Brown Adipose Tissue of Monosodium Glutamate-Obese Mice.

DOI Web Site Web Site Web Site Web Site ほか1件をすべて表示 一部だけ表示 被引用文献2件 参考文献25件
  • Tsukahara Fujiko
    Department of Pharmacology, Tokyo Women’s Medical University, School of Medicine
  • Uchida Yoko
    Department of Pharmacology, Tokyo Women’s Medical University, School of Medicine
  • Ohba Ken-ichi
    Department of Pharmacology, Tokyo Women’s Medical University, School of Medicine
  • Ogawa Akira
    Department of Pharmacology, Tokyo Women’s Medical University, School of Medicine
  • Yoshioka Toshimasa
    Department of Pharmacology, Tokyo Women’s Medical University, School of Medicine
  • Muraki Takamura
    Department of Pharmacology, Tokyo Women’s Medical University, School of Medicine

書誌事項

タイトル別名
  • Effect of Acute Cold Exposure and Norep

この論文をさがす

抄録

Abnormal regulation of mitochondrial uncoupling protein (UCP) gene expression was studied in brown adipose tissue (BAT) of monosodium glutamate (MSG)-induced obese mice. UCP mRNA levels in control mice increased markedly after acute cold exposure; however, MSG-obese mice showed an impaired response. In contrast, an injection of norepinephrine (NE) induced a comparable increase in UCP mRNA levels in control and MSG-obese mice. These results suggest that the impairment in the cold-induced increase in UCP mRNA is due to a deficient sympathetic input to BAT and/or to a diminished response of BAT to endogenous NE, which constitutes the mechanism of impaired thermoregulation in obese mice in a cold environment.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 77 (3), 247-249, 1998

    公益社団法人 日本薬理学会

被引用文献 (2)*注記

もっと見る

参考文献 (25)*注記

もっと見る

詳細情報

問題の指摘

ページトップへ