Histamine H_3 Receptor-Mediated Inhibition of Excitatory Synaptic Transmission in the Rat Dentate Gyrus In Vivo

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Author(s)

Abstract

We investigated the effects of histamine H<SUB>3</SUB>-receptor ligands on hippocampal synaptic transmission by using anesthetized rats in vivo. The medial perforant path was stimulated, and the population excitatory postsynaptic potential (pEPSP) and population spike were recorded from the granule cell layer of the dentate gyrus. Intracerebroventricular injection of the H<SUB>3</SUB>-receptor agonist (<I>R</I>)-α-methylhistamine decreased both the pEPSP and population spike, while H<SUB>3</SUB>-receptor antagonists, clobenpropit and thioperamide, increased both the pEPSP and population spike. These results suggest that the histaminergic system plays a role in inhibition of hippocampal synaptic excitation via the H<SUB>3</SUB> receptor.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 77(3), 251-255, 1998-07-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008193306
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4525742
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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