Irsogladine Maleate May Preserve Gastric Mucosal Hydrophobicity Against Ethanol in Phospholipids Independent Way in Rats

• Tatsumi Yoshihide

  Third Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Tanino Masamichi

  Third Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Kodama Tadashi

  Third Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Kashima Kei

  Third Department of Internal Medicine, Kyoto Prefectural University of Medicine

• Katsura Masashi

  Department of Pharmacology, Kawasaki Medical School

• Okuma Seitaro

  Department of Pharmacology, Kawasaki Medical School

書誌事項

タイトル別名

• Irsogladine Maleate May Preserve Gastric Mucosal Hydrophobicity Against Ethanol in Phospholipids Independent Way in Rat.
• Irsogladine Maleate May Preserve Gastri

抄録

Irsogladine maleate (IM) has been used as a mucosal protective agent, whose action is partially explained as enhancement of mucosal blood flow, increase of cellular cyclic AMP and facilitation of gap-junctional intercellular communication. Effect of IM on rat gastric mucosal hydrophobicity, one of the mucosal barrier properties, was investigated, in comparison with that of 16, 16-dimethyl prostaglandin E₂ (dmPGE₂). IM alone had no effect on mucosal hydrophobicity and mucosal phospholipids content. dmPGE₂ alone did not change mucosal hydrophobicity significantly, but remarkably increased mucosal surface-active phospholipids. Intragastric administration of absolute ethanol significantly decreased gastric mucosal hydrophobicity and mucosal phospholipids content. IM could prevent the decrease in mucosal hydrophobicity by ethanol, maintaining the surface mucus gel layer and mucosal surface phospholipids almost as non-damaged control levels, whereas dmPGE₂ also prevented the decrease in mucosal hydrophobicity by ethanol, with the surface epithelium being partially exfoliated and mucosal surface-active phospholipids showing remarkable enhancement. These results suggest that IM may preserve gastric mucosal hydrophobicity against ethanol, not through enhancement of mucosal phospholipids content like prostaglandin, but possibly through its reported stabilization action to the epithelial cell lining, which may preserve the surface epithelium with the mucous gel layer containing surface-active phospholipids, a possible origin of mucosal hydrophobicity.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 77 (4), 293-299, 1998

  公益社団法人 日本薬理学会

キーワード

• Mucosal hydrophobicity
• Phospholipid
• Irsogladine maleate

詳細情報

• CRID: 1390282679263665152
• NII論文ID: 10008193452
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.77.293
• COI: 1:CAS:528:DyaK1cXls1Ons70%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 4547529
• PubMed: 9749930
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4547529
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819310856?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819310856?httpAccept=text/plain
• Web Site: https://www.jstage.jst.go.jp/article/jjp/77/4/77_4_293/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999002600
• 本文言語コード: en
• データソース種別:
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