Endothelin Receptors in Testosterone-Induced Prostatic Hypertrophy in Rats

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Abstract

Endothelin receptors were characterized in rat prostate and potential modification of these receptors was investigated in prostatic hypertrophy induced by testosterone. Both ET<SUB>A</SUB> and ET<SUB>B</SUB> endothelin receptor mRNA were detected in rat prostate, whereas binding experiments show the presence of only ET<SUB>A</SUB> receptors. Testosterone administration produced a 75% increase in prostate weight. Although the density of prostatic endothelin receptors was decreased from 348±75.0 fmol/mg protein in control rats to 252±39.9 fmol/mg protein in testosterone-treated animals, the total amount of receptors per prostate was unchanged. The steady-state level of ET<SUB>A</SUB>- and ET<SUB>B</SUB>-receptor mRNA was not altered by testosterone treatment. These results suggest that endothelin receptors are not affected in prostatic hypertrophy induced by testosterone.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 77(4), 307-310, 1998-08-01

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008193489
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4547531
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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