Endothelin Receptors in Testosterone-Induced Prostatic Hypertrophy in Rats
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Endothelin receptors were characterized in rat prostate and potential modification of these receptors was investigated in prostatic hypertrophy induced by testosterone. Both ET<SUB>A</SUB> and ET<SUB>B</SUB> endothelin receptor mRNA were detected in rat prostate, whereas binding experiments show the presence of only ET<SUB>A</SUB> receptors. Testosterone administration produced a 75% increase in prostate weight. Although the density of prostatic endothelin receptors was decreased from 348±75.0 fmol/mg protein in control rats to 252±39.9 fmol/mg protein in testosterone-treated animals, the total amount of receptors per prostate was unchanged. The steady-state level of ET<SUB>A</SUB>- and ET<SUB>B</SUB>-receptor mRNA was not altered by testosterone treatment. These results suggest that endothelin receptors are not affected in prostatic hypertrophy induced by testosterone.
- The Japanese Journal of Pharmacology
The Japanese Journal of Pharmacology 77(4), 307-310, 1998-08-01
The Japanese Pharmacological Society