Endothelin Receptors in Testosterone-Induced Prostatic Hypertrophy in Rats.

• Auger-Pourmarin Lydie

  Institut Henri Beaufour, 5, Avenue du Canada, Z.A. de Courtaboeuf

• Roubert Pierre

  Institut Henri Beaufour, 5, Avenue du Canada, Z.A. de Courtaboeuf

• Chabrier Pierre Etienne

  Institut Henri Beaufour, 5, Avenue du Canada, Z.A. de Courtaboeuf

書誌事項

タイトル別名

• Endothelin Receptors in Testosterone-In

抄録

Endothelin receptors were characterized in rat prostate and potential modification of these receptors was investigated in prostatic hypertrophy induced by testosterone. Both ET_A and ET_B endothelin receptor mRNA were detected in rat prostate, whereas binding experiments show the presence of only ET_A receptors. Testosterone administration produced a 75% increase in prostate weight. Although the density of prostatic endothelin receptors was decreased from 348±75.0 fmol/mg protein in control rats to 252±39.9 fmol/mg protein in testosterone-treated animals, the total amount of receptors per prostate was unchanged. The steady-state level of ET_A- and ET_B-receptor mRNA was not altered by testosterone treatment. These results suggest that endothelin receptors are not affected in prostatic hypertrophy induced by testosterone.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 77 (4), 307-310, 1998

  公益社団法人 日本薬理学会

キーワード

• Prostate
• Endothelin receptor
• Testosterone

詳細情報

• CRID: 1390001204286957824
• NII論文ID: 10008193489
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.77.307
• COI: 1:CAS:528:DyaK1cXls1Ons7s%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 4547531
• PubMed: 9749932
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4547531
• Web Site: https://api.elsevier.com/content/article/PII:S002151981931087X?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S002151981931087X?httpAccept=text/plain
• Web Site: https://www.jstage.jst.go.jp/article/jjp/77/4/77_4_307/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999014144
• 本文言語コード: en
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