17β-Estradiol Alters Isoproterenol-Induced Relaxation in Rat Aortic Rings

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Author(s)

Abstract

Female Wistar rats were treated with 17β-estradiol (E<SUB>2</SUB>) (10 μg, s.c.) or with sesame oil for 3 days. The relaxation induced by isoproterenol (10<SUP>-9</SUP>-3×10<SUP>-6</SUP> M) in aortae precontracted with norepinephrine was significantly suppressed in aortae from E<SUB>2</SUB>-treated rats compared with the relaxation in those from control rats. <I>N</I><SUP>G</SUP>-Nitro-L-arginine, a nitric oxide synthase inhibitor, inhibited isoproterenol-induced relaxation in aortae from both E<SUB>2</SUB>-treated and control rats. Metyrapone, a cytochrome P-450 monooxygenase inhibitor, inhibited it in aortae from control rats, but metyrapone enhanced the maximum relaxation in aortae from E<SUB>2</SUB>-treated rats. These results suggest that E<SUB>2</SUB> modulates isoproterenol-induced vasodilation through nitric oxide and cytochrome P-450-dependent metabolites.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 77(4), 311-313, 1998-08-01

    The Japanese Pharmacological Society

References:  15

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008193505
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4547532
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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