Production of Superoxide and Nitric Oxide by Alveolar Macrophages in the Bleomycin-Induced Interstitial Pneumonia Mice Model

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Author(s)

Abstract

To elucidate the potential role of superoxide (O<SUB>2</SUB><SUP>-</SUP>) and nitric oxide (NO) in the pathogenesis of interstitial pneumonia, the quantity of O<SUB>2</SUB><SUP>-</SUP> and NO produced by the alveolar macrophages (AM) were determined in the bleomycin (BLM)-induced interstitial pneumonia mouse model. The production of O<SUB>2</SUB><SUP>-</SUP> and NO increased on days 7, 14 and 21 after BLM injection. Strong expression of peroxynitrite (ONOO<SUP>-</SUP>) was seen in AM by using immunostaining for nitrotyrosine. The hydroxyproline contents increased on day 21 after BLM injection. O<SUB>2</SUB><SUP>-</SUP> and NO are thought to play an important role in the pathology of fibrosis.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 78(1), 69-73, 1998-09

    The Japanese Pharmacological Society

References:  13

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008193785
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4565705
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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