Involvement of N-Type Voltage-Activated Ca^<2+> Channels in the Release of Endogenous Noradrenaline from the Isolated Vascularly Perfused Rat Stomach

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Author(s)

Abstract

We characterized the voltage-activated Ca<SUP>2+</SUP> channels involved in noradrenaline (NA) release from gastric sympathetic neurons using isolated, vascularly perfused rat stomach. The evoked NA release by electrical stimulation of periarterial nerves was abolished by calcium removal from the perfusion medium and by cadmium. ω-Conotoxin GVIA (N-type Ca<SUP>2+</SUP>-channel blocker) effectively and ω-conotoxin MVIIC (N/P/Q-type blocker) slightly inhibited the evoked NA, while ω-agatoxin IVA (P-type blocker) had no effect. These results suggest that ω-conotoxin GVIA and ω-conotoxin MVIIC-sensitive N-type Ca<SUP>2+</SUP> channels are involved in NA release from the rat gastric sympathetic nerve terminals.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 78(1), 75-77, 1998-09

    The Japanese Pharmacological Society

References:  14

Cited by:  3

Codes

  • NII Article ID (NAID)
    10008193799
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4565706
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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