Protective Effect of the Mold Monascus Anka Against Acetaminophen-Induced Liver Toxicity in Rats

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Author(s)

Abstract

Antioxidant and hepatoprotective actions of the mold <I>Monascus anka</I> (also called <I>Beni-Koji</I> in Japan) against acetaminophen (AAP)-induced liver toxicity were investigated. Serum aspartate aminotransferase and glutathione <I>S</I>-transferase (GST) activities increased by AAP (180 mg/kg, i.p.) treatment were depressed when the <I>Beni-Koji</I> preparation (4 ml/kg, i.p.) was given 15 and 1 hr before AAP administration. The decrease in liver cytosolic GST activity by AAP, reflecting the release of the enzyme into serum, was also blocked by the mold. Cytochrome P450 activity was inhibited by the <I>Beni-Koji</I> preparation. These results suggest that <I>M. anka</I> prevents AAP-induced liver toxicity by both antioxidant action and the inhibition of AAP metabolism.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 78(1), 79-82, 1998-09

    The Japanese Pharmacological Society

References:  14

Codes

  • NII Article ID (NAID)
    10008193814
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4565707
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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