Inhibitory Effect of Endomorphin-1 and -2 on Acetylcholine Release From Myenteric Plexus of Guinea Pig Ileum

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Author(s)

    • Nishiwaki Hideyuki NISHIWAKI Hideyuki
    • Kawanishi Pharma Research Instilute, Nippon Boehringer Ingelheim Co., Ltd., Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University
    • TAKEUCHI Tadayoshi
    • Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Department of Molecular Physiology and Biochemistry, Research Institute for Advanced Science and Technology, Osaka Prefecture University
    • HATA Fumiaki
    • Department of Veterinary Pharmacology, College of Agriculture, Osaka Prefecture University, Department of Molecular Physiology and Biochemistry, Research Institute for Advanced Science and Technology, Osaka Prefecture University

Abstract

Endomorphin-1 and -2, putative endogenous ligands for the mu-opioid receptor, inhibited acetylcholine (ACh) release evoked by electrical field stimulation (EFS) at 1 Hz, which partially activates muscarinic autoreceptors, but not at 10 Hz, which fully activates muscarinic autoreceptors, in longitudinal muscle with the myenteric plexus (LMMP) preparations of guinea pig ileum. After blockade of autoinhibition by atropine, the peptides also inhibited EFS-evoked ACh release at 10 Hz. The inhibitory effects on ACh release were abolished by the mu-opioid antagonist cyprodime. These results suggest that endomorphin-1 and -2 inhibit ACh release from LMMP preparations of guinea pig ileum and that the mechanism of the inhibition must have a component in common with muscarinic autoinhibition.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 78(1), 83-86, 1998-09

    The Japanese Pharmacological Society

References:  15

Codes

  • NII Article ID (NAID)
    10008193829
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4565708
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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