Effect of Gosha-jinki-gan, a Kampo Medicine, on Enhanced Platelet Aggregation in Streptozotocin-Induced Diabetic Rats
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We evaluated the effects of <I>Gosha-jinki-gan</I> on platelet aggregation in streptozotocin-induced diabetic rats. Enhanced ADP (2 μM)-induced aggregation of platelets obtained from diabetic rats was inhibited by a single treatment with <I>Gosha-jinki-gan</I> (0.3, 1.5 g/kg, p.o.). The anti-platelet aggregatory effect of <I>Gosha-jinki-gan</I> (1.5 g/kg, p.o.) was attenuated by simultaneous administration of atropine (1 mg/kg, i.p.) and was abolished by combination of atropine with Hoe 140 (250 μg/kg×2, i.p.), a bradykinin B<SUB>2</SUB> receptor antagonist or L-NAME (10 mg/kg, i.p.), an inhibitor of nitric oxide-synthase. These results suggested that <I>Gosha-jinki-gan</I> could improve platelet aggregation in diabetes through increased production of nitric oxide via bradykinin B<SUB>2</SUB>-receptors and muscarinic acetylcholine receptors.
- The Japanese Journal of Pharmacology
The Japanese Journal of Pharmacology 78(1), 87-91, 1998-09
The Japanese Pharmacological Society