Involvement of μ-Receptor in Endogenous Opioid Peptide-Mediated Inhibition of Acetylcholine Release From the Rat Stomach

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Author(s)

Abstract

We examined the effect of endogenous opioid peptides on vagally evoked release of acetylcholine (ACh) from the isolated, vascularly perfused rat stomach. The vagus nerves were electrically stimulated twice at 2.5 Hz for 2 min, and test substances were administered during the second stimulation. β-Endorphin (10<SUP>-7</SUP> and 3×10<SUP>-7</SUP> M), an endogenous nonselective agonist of μ-receptors, inhibited the release of ACh. However, [Leu<SUP>5</SUP>]-enkephalin, an endogenous nonselective agonist of δ-receptors, and U-50488, a κ-receptor agonist, had no effect at a higher dose of 10<SUP>-6</SUP> M. β-Endorphin-induced inhibition was abolished by naloxone. Endomorphins 1 and 2 (3×10<SUP>-7</SUP> and 10<SUP>-6</SUP> M), endogenous selective agonists of μ-receptors, also inhibited the release of ACh. These results suggest that the μ-receptor is involved in the endogenous opioid peptide-induced inhibition of the release of ACh from the rat stomach.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 78(1), 93-95, 1998-09

    The Japanese Pharmacological Society

References:  14

Codes

  • NII Article ID (NAID)
    10008193858
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4565710
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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