Mouse Paw Edema Induced by a Novel Bradykinin Agonist and Its Inhibition by B2-Antagonists
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A novel non-peptide bradykinin B2-receptor agonist, FR190997 (8-[2, 6-dichloro-3-[<I>N</I>-[(<I>E</I>)4-(<I>N</I>-methylcarbamoyl)cinnamidoacetyl]-<I>N</I>-methylamino]benzyloxy]-2-methyl-4-(2-pyridylmethoxy) quinoline), induced dose-dependent and longer-lasting swelling than bradykinin in the mouse paw. The swelling, peaking around 30 min, was suppressed dose-dependently by intraperitoneal administration of FR173657, a novel non-peptide B2-receptor antagonist. A known B2-antagonist, Hoe 140, also significantly suppressed this edema. The result indicates that the novel B2-agonist FR190997, being more stable than bradykinin, could induce plasma exudation locally in mice via the B2-receptor as a substitute for bradykinin.
- The Japanese Journal of Pharmacology
The Japanese Journal of Pharmacology 78(1), 109-111, 1998-09
The Japanese Pharmacological Society