Regional and Functional Differences of 5-Hydroxytryptamine-Receptor Subtypes in Guinea Pig Stomach

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Author(s)

Abstract

Functions and the presence of 5-hydroxytryptamine (5-HT) receptors in the fundus, corpus and antrum of the guinea pig stomach were examined by measuring contractile force and acetylcholine (ACh) release. Stimulation of the 5-HT<SUB>1</SUB> receptor caused tetrodotoxin (TTX)-insensitive relaxations in the preparations from 3 regions. Stimulation of the 5-HT<SUB>2</SUB> receptor caused TTX-insensitive contractions in the preparations of fundus and antrum. Stimulation of 5-HT<SUB>3</SUB> receptors caused contractions that were sensitive to TTX and atropine and enhanced the outflow of [<SUP>3</SUP>H]ACh from preparations of only antrum. Stimulation of 5-HT<SUB>4</SUB> receptors caused contractions of antral strips and decreased relaxations of corporal strips and enhanced the outflow of [<SUP>3</SUP>H]ACh from the preparations of both corpus and antrum. In the guinea pig stomach, the fundus possesses relaxant 5-HT<SUB>1</SUB> receptor < contractile 5-HT<SUB>2</SUB> receptors and caused the contractile response to 5-HT. The corpus possesses relaxant 5-HT<SUB>1</SUB> receptors and relaxant receptors other than 5-HT<SUB>1</SUB>, 5-HT<SUB>2</SUB>, 5-HT<SUB>3</SUB> and 5-HT<SUB>4</SUB> receptors > contractile 5-HT<SUB>4</SUB> receptor, and therefore 5-HT caused relaxations. The antrum possesses relaxant 5-HT<SUB>1</SUB> receptor < contractile 5-HT<SUB>2</SUB>, 5-HT<SUB>3</SUB> and 5-HT<SUB>4</SUB> receptors, and thus 5-HT caused contractions.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 79(1), 41-49, 1999-01

    The Japanese Pharmacological Society

References:  21

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008194099
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4636904
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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