ATP-Sensitive Potassium Channels Regulate In Vivo Dopamine Release in Rat Striatum.
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- Zhu Dawn Xiao-Dong
- Neurological and Urological Diseases Research, Abbott Laboratories
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- Sullivan James P.
- Neurological and Urological Diseases Research, Abbott Laboratories
Bibliographic Information
- Other Title
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- ATPSensitive Potasium Channels Regulate in Vivo Dopamine Release in Rat Striatum
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Abstract
ATP-sensitive K+ channels (KATP) are distributed in a variety of tissues including smooth muscle, cardiac and skeletal muscle, pancreatic β-cells and neurons. Since KATP channels are present in the nigrostriatal dopamine (DA) pathway, the effect of potassium-channel modulators on the release of DA in the striatum of conscious, freely-moving rats was investigated. The extracellular concentration of DA was significantly decreased by the KATP-channel opener (-)-cromakalim but not by diazoxide. (-)-Cromakalim was effective at 100 and 1000 μM concentrations, and the maximum decrease was 54% below baseline. d-Amphetamine significantly increased extracellular DA levels at the doses of 0.75 and 1.5 mg/kg, s.c. with a 770% maximum increase. (-)-Cromakalim had no effect on d-amphetamine-induced DA release, while glyburide, a KATP blocker, significantly potentiated the effects of a low dose of d-amphetamine. These data indicate that K+ channels present in the nigrostriatal dopaminergic terminals modulate basal release as well as evoked release of DA.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 79 (1), 59-64, 1999
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001204284571520
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- NII Article ID
- 10008194153
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1MXns1yntQ%3D%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4636916
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- PubMed
- 10082318
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4636916
- https://api.elsevier.com/content/article/PII:S0021519819309898?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819309898?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/79/1/79_1_59/_pdf
- https://search.jamas.or.jp/link/ui/1999133755
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed