Central Nervous System-Mediated Hyperglycemic Effects of NIK-247, a Cholinesterase Inhibitor, and MKC-231, a Choline Uptake Enhancer, in Rats

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Author(s)

Abstract

We investigated the effects of intracerebroventricular administration of NIK-247 (9-amino-2, 3, 5, 6, 7, 8-hexahydro-1<I>H</I>-cyclo-penta(<I>b</I>)-quinoline monohydrate hydrochloride; a cholinesterase inhibitor) or MKC-231 (2-(2-oxypyrrolidin-l-yl)-<I>N</I>-(2, 3-dimethyl-5, 6, 7, 8-tetrahydrofuro[2, 3-<I>b</I>]quinolin-4-yl) acetoamide; a choline uptake enhancer) on plasma glucose level in comparison with that of neostigmine administration in rats. The extents of NIK-247- and MKC-231-induced hyperglycemia were considerably less than that by neostigmine, suggesting that the potencies of the drugs to produce the peripheral hyperglycemia may be pharmacologically negligible.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 79(1), 113-115, 1999-01

    The Japanese Pharmacological Society

References:  10

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008194331
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4637060
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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