Central Nervous System-Mediated Hyperglycemic Effects of NIK-247, a Cholinesterase Inhibitor, and MKC-231, a Choline Uptake Enhancer, in Rats

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抄録

We investigated the effects of intracerebroventricular administration of NIK-247 (9-amino-2, 3, 5, 6, 7, 8-hexahydro-1<I>H</I>-cyclo-penta(<I>b</I>)-quinoline monohydrate hydrochloride; a cholinesterase inhibitor) or MKC-231 (2-(2-oxypyrrolidin-l-yl)-<I>N</I>-(2, 3-dimethyl-5, 6, 7, 8-tetrahydrofuro[2, 3-<I>b</I>]quinolin-4-yl) acetoamide; a choline uptake enhancer) on plasma glucose level in comparison with that of neostigmine administration in rats. The extents of NIK-247- and MKC-231-induced hyperglycemia were considerably less than that by neostigmine, suggesting that the potencies of the drugs to produce the peripheral hyperglycemia may be pharmacologically negligible.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 79(1), 113-115, 1999-01

    公益社団法人 日本薬理学会

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各種コード

  • NII論文ID(NAID)
    10008194331
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4637060
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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