Effect of Cysteine Protease of Porphyromonas gingivalis on Adhesion Molecules in Gingival Epithelial Cells

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Author(s)

Abstract

We examined the effect of cysteine protease of <I>Porphyromonas gingivalis</I> (<I>P. gingivalis</I>) on cell adhesion molecules including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and very late antigen-4 (VLA-4) of human gingival epithelial cells. The cells were incubated for 48 hr with or without <I>P. gingivalis</I> protease. Their cell adhesion molecule expression levels were increased at 12 hr, but decreased at 18 - 48 hr. This result suggests that protease degrades cell adhesion molecules. After the stimulation with protease for 12 hr, <I>P. gingivalis</I> fimbrial binding to a monolayer of the cells was effectively inhibited by the addition of the cell adhesion molecules, suggesting the fimbrial binding to the cells occurred through cell surface adhesion molecules.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 80(1), 75-79, 1999-05-01

    The Japanese Pharmacological Society

References:  15

Cited by:  5

Codes

  • NII Article ID (NAID)
    10008194665
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4733155
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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