Postmenopause-Like Bone Loss by Mammary Carcinoma Walker256/S Which Secretes Luteinizing Hormone-Releasing Hormone

Access this Article

Author(s)

    • SAITOH Yukie
    • Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kanazawa University
    • KASUGAI Shohei
    • Department of Pharmacology, Faculty of Dentistry, Tokyo Medical and Dental University
    • OHYA Keiichi
    • Department of Pharmacology, Faculty of Dentistry, Tokyo Medical and Dental University

Abstract

When Walker 256/S carcinosarcoma (W256/S) was subcutaneously inoculated into the back of mature female Wistar Imamichi rats (10-week-old), the tumor grew rapidly and caused increases in the urinary excretions of calcium and hydroxyproline, without changes in the serum concentrations of calcium and inorganic phosphorus. Furthermore, osteoporosis-like changes in the femurs and decrease in uterus weight were observed, as previously reported for W256/S-bearing young rats. In the healthy mature female rats, the estrus cycle passed through four stages (proestrus, estrus, metestrus and diestrus) within 4 to 5 days, with a peak of serum estradiol and progesterone levels in the proestrus stage. On the other hand, after subcutaneous inoculation of W256/S into the rats, the estrus cycle tended to pause upon the metestrus or diestrus stage, accompanied with significantly low estradiol and progesterone levels in serum. W256/S tumor produced and secreted luteinizing hormone-releasing hormone (LH-RH). In conclusion, it seems that the ectopical secretion of LH-RH from the tumor resulted in the decrease in the secretion of gonadotropic hormones, following low level of sex hormones and stopping the estrus cycle. Therefore, W256/S-bearing rats may be a model for osteoporosis of hypoovarianism or postmenopause.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 80(2), 119-125, 1999-06-01

    The Japanese Pharmacological Society

References:  23

Codes

  • NII Article ID (NAID)
    10008194846
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00215198
  • NDL Article ID
    4771921
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
Page Top