Biphasic Relaxation Caused by Electrical Field Stimulation of the Mesenteric Arteries of Rats

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Author(s)

    • FUKUMITSU Ai
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
    • HONDA Kenji
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
    • TAKANO Yukio
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
    • KAMIYA Hiro-o
    • Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

Abstract

Electrical field stimulation (EFS) caused biphasic relaxation, first transient and then sustained, of rat mesenteric arteries precontracted by prostaglandin (PG) F<SUB>2α</SUB>. The transient relaxation was reduced about 45%, and the sustained relaxation was not observed after endothelium denudation of the arteries. <I>N</I><SUP>ω</SUP>-Nitro-L-arginine (L-NOARG) inhibited the biphasic relaxation induced by EFS. At 1 - 100 μM, L-NOARG inhibited the transient relaxation more than the sustained relaxation. Methylene blue inhibited the biphasic relaxation and at 100 μM, L-NOARG abolished the transient relaxation. These results suggest that the transient relaxation mainly involves nitric oxide (NO), whereas the sustained relaxation involves both NO and some other factor(s).

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 80(2), 169-172, 1999-06-01

    The Japanese Pharmacological Society

References:  14

Codes

  • NII Article ID (NAID)
    10008195027
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    SHO
  • ISSN
    00215198
  • NDL Article ID
    4771986
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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