Effects of Activation of Renal Adenosine A2 Receptor on Renal Function and Renin Release in Dogs

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Author(s)

Abstract

Direct effects of adenosine A2 receptor activation on renal function were examined in dogs. When renal perfusion pressure was maintained constant at 100 mmHg, renal administration of a selective A2 receptor agonist, CGS 21680C (sodium salt of CGS 21680, 2-[<I>p</I>-(2-carboxyethyl) phenethylamino]-5'-<I>N</I>-ethylcarboxamido adenosine) (1 μg·kg<SUP>-1</SUP>·min<SUP>-1</SUP>), although it decreased blood pressure by 20 mmHg, increased renal blood flow and renin release, whereas glomerular filtration rate and urine flow were unaffected. These results suggest that stimulation of renal A2 receptor led to both afferent and efferent arteriolar dilatation, whereas renal A2 receptor plays a minor role in urine formation. CGS 21680C induced renin release and tachycardia that were blocked by propranolol, indicating these effects of A2 receptor stimulation appeared to be indirect.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 80(2), 173-176, 1999-06-01

    The Japanese Pharmacological Society

References:  12

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008195042
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4771989
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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